What do you recomend for me, my Imitrex is 50 mg's, I can take another one in 1 hour if not gone by then. Read More I'm fortunate that I get the aura before the migraine so I know to take the 2 tylenol and coke immediately when the aura and vision problems appear and so it takes the migraine away before it actually hits full force. This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid taking aspirin while you are taking sumatriptan and naproxen. How to use Imitrex. Read the Patient Information Leaflet if available from your pharmacist before you start taking sumatriptan and each time you get a refill. They diagnosed me with 'complicated' migraines, so I understand you can't take something in the class of Imitrex, but no one has ever prescribed anything for me. So I just take Excedrin Migraine and ride it out. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Tyson on can i take sumatriptan with excedrin: These medications are both antiinflammatory and should never be used together. Avoid taking aspirin while you are taking sumatriptan and naproxen. Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to naproxen. What other drugs will affect Imitrex? Using Imitrex while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called serotonin syndrome, which can be fatal. Aspirin uses. You may use aspirin to help treat minor pain. A typical treatment with aspirin is four to eight 81-mg tablets every four hours or one to two 325-mg tablets every four hours. Summary. Drug interactions are reported among people who take Imitrex and Tylenol together. This study is created by eHealthMe based on reports of 471 people who take Imitrex and Tylenol from FDA, and is updated regularly. You should not mix Acetaminophen (Tylenol) and Acetylsalicylic acid (Aspirin). The reason for this is l ong term renal (kidney) damage. What happens in the Tylenol induces the formation of free.